| 1 | 18/08/2010 19:00 | OLSA Brakel - SK Sint-Niklaas | 2-2 | |
| 2 | 25/08/2010 18:30 | SK Sint-Niklaas - Verbr. Geel-Meerhout | 1-3 | |
| 3 | 29/08/2010 15:00 | KSV Temse - SK Sint-Niklaas | 1-1 | |
| 4 | 05/09/2010 15:00 | SK Sint-Niklaas - SC Wielsbeke | 1-0 | |
| 5 | 12/09/2010 15:00 | R. Cappellen FC - SK Sint-Niklaas | - | |
| 6 | 19/09/2010 15:00 | SK Sint-Niklaas - VC Eendracht Aalst 2002 | - | |
| 7 | 26/09/2010 15:00 | KVV Coxyde - SK Sint-Niklaas | - | |
| 8 | 03/10/2010 15:30 | SK Sint-Niklaas - KSV Oudenaarde | - | |
| 9 | 10/10/2010 15:00 | KRC Waregem - SK Sint-Niklaas | - | |
| 10 | 17/10/2010 15:00 | SK Sint-Niklaas - KFC Dessel Sport | - | |
| 11 | 23/10/2010 20:00 | Hoogstraten VV - SK Sint-Niklaas | - | |
| 12 | 31/10/2010 15:00 | SK Sint-Niklaas - KM Torhout 92 | - | |
| 13 | 06/11/2010 20:00 | KMSK Deinze - SK Sint-Niklaas | - | |
| 14 | 13/11/2010 14:30 | SK Sint-Niklaas - VW Hamme | - | |
| 15 | 21/11/2010 14:30 | SK Sint-Niklaas - KSK Ronse | - | |
| 16 | 28/11/2010 15:00 | KSV Bornem - SK Sint-Niklaas | - | |
| 17 | 05/12/2010 14:30 | KFC Izegem - SK Sint-Niklaas | - | |
| 18 | 12/12/2010 14:30 | SK Sint-Niklaas - OLSA Brakel | - | |
| 19 | 18/12/2010 20:00 | Verbr. Geel-Meerhout - SK Sint-Niklaas | - | |
| 20 | 09/01/2011 14:30 | SK Sint-Niklaas - KSV Temse | - | |
| 21 | 16/01/2011 14:30 | SC Wielsbeke - SK Sint-Niklaas | - | |
| 22 | 23/01/2011 14:30 | VC Eendracht Aalst 2002 - SK Sint-Niklaas | - | |
| 23 | 30/01/2011 14:30 | SK Sint-Niklaas - R. Cappellen FC | - | |
| 24 | 06/02/2011 15:00 | SK Sint-Niklaas - KVV Coxyde | - | |
| 25 | 20/02/2011 15:00 | KSV Oudenaarde - SK Sint-Niklaas | - | |
| 26 | 27/02/2011 15:00 | SK Sint-Niklaas - KRC Waregem | - | |
| 27 | 05/03/2011 19:30 | KFC Dessel Sport - SK Sint-Niklaas | - | |
| 28 | 20/03/2011 15:00 | SK Sint-Niklaas - Hoogstraten VV | - | |
| 29 | 26/03/2011 19:30 | KM Torhout 92 - SK Sint-Niklaas | - | |
| 30 | 03/04/2011 15:00 | SK Sint-Niklaas - KMSK Deinze | - | |
| 31 | 17/04/2011 15:00 | SK Sint-Niklaas - KSV Bornem | - | |
| 32 | 01/05/2011 15:00 | SK Sint-Niklaas - KFC Izegem | - | |
| 33 | 08/05/2011 15:00 | KSK Ronse - SK Sint-Niklaas | - | |
