| 1 | 18/08/2010 19:00 | KRC Waregem - KFC Dessel Sport | 2-1 | |
| 2 | 25/08/2010 20:00 | KFC Dessel Sport - OLSA Brakel | 3-0 | |
| 3 | 29/08/2010 16:00 | KFC Dessel Sport - Hoogstraten VV | 2-0 | |
| 4 | 04/09/2010 19:30 | KM Torhout 92 - KFC Dessel Sport | 1-1 | |
| 5 | 11/09/2010 19:30 | KFC Dessel Sport - KMSK Deinze | - | |
| 6 | 19/09/2010 15:00 | VW Hamme - KFC Dessel Sport | - | |
| 7 | 25/09/2010 19:30 | KFC Dessel Sport - KSV Bornem | - | |
| 8 | 03/10/2010 15:00 | KSK Ronse - KFC Dessel Sport | - | |
| 9 | 09/10/2010 19:30 | KFC Dessel Sport - KFC Izegem | - | |
| 10 | 17/10/2010 15:00 | SK Sint-Niklaas - KFC Dessel Sport | - | |
| 11 | 23/10/2010 19:30 | KFC Dessel Sport - Verbr. Geel-Meerhout | - | |
| 12 | 30/10/2010 20:00 | KSV Temse - KFC Dessel Sport | - | |
| 13 | 06/11/2010 19:30 | KFC Dessel Sport - SC Wielsbeke | - | |
| 14 | 14/11/2010 15:00 | R. Cappellen FC - KFC Dessel Sport | - | |
| 15 | 21/11/2010 15:00 | KVV Coxyde - KFC Dessel Sport | - | |
| 16 | 27/11/2010 19:30 | KFC Dessel Sport - VC Eendracht Aalst 2002 | - | |
| 17 | 04/12/2010 19:30 | KFC Dessel Sport - KSV Oudenaarde | - | |
| 18 | 11/12/2010 19:30 | KFC Dessel Sport - KRC Waregem | - | |
| 19 | 19/12/2010 14:30 | OLSA Brakel - KFC Dessel Sport | - | |
| 20 | 08/01/2011 20:00 | Hoogstraten VV - KFC Dessel Sport | - | |
| 21 | 15/01/2011 19:30 | KFC Dessel Sport - KM Torhout 92 | - | |
| 22 | 23/01/2011 14:30 | KFC Dessel Sport - VW Hamme | - | |
| 23 | 29/01/2011 20:00 | KMSK Deinze - KFC Dessel Sport | - | |
| 24 | 06/02/2011 15:00 | KSV Bornem - KFC Dessel Sport | - | |
| 25 | 19/02/2011 19:30 | KFC Dessel Sport - KSK Ronse | - | |
| 26 | 27/02/2011 15:00 | KFC Izegem - KFC Dessel Sport | - | |
| 27 | 05/03/2011 19:30 | KFC Dessel Sport - SK Sint-Niklaas | - | |
| 28 | 19/03/2011 20:00 | Verbr. Geel-Meerhout - KFC Dessel Sport | - | |
| 29 | 26/03/2011 19:30 | KFC Dessel Sport - KSV Temse | - | |
| 30 | 03/04/2011 15:00 | SC Wielsbeke - KFC Dessel Sport | - | |
| 31 | 09/04/2011 19:30 | KFC Dessel Sport - R. Cappellen FC | - | |
| 32 | 17/04/2011 15:00 | VC Eendracht Aalst 2002 - KFC Dessel Sport | - | |
| 33 | 01/05/2011 15:00 | KSV Oudenaarde - KFC Dessel Sport | - | |
| 34 | 08/05/2011 15:00 | KFC Dessel Sport - KVV Coxyde | - | |
