| 1 | 18/08/2010 20:00 | KSV Temse - KSK Ronse | 2-0 | |
| 2 | 25/08/2010 18:30 | KFC Izegem - KSV Temse | 1-1 | |
| 3 | 29/08/2010 15:00 | KSV Temse - SK Sint-Niklaas | 1-1 | |
| 4 | 04/09/2010 20:00 | Verbr. Geel-Meerhout - KSV Temse | 3-1 | |
| 5 | 12/09/2010 15:00 | OLSA Brakel - KSV Temse | - | |
| 6 | 18/09/2010 20:00 | KSV Temse - SC Wielsbeke | - | |
| 7 | 26/09/2010 15:00 | R. Cappellen FC - KSV Temse | - | |
| 8 | 03/10/2010 15:00 | KSV Temse - VC Eendracht Aalst 2002 | - | |
| 9 | 10/10/2010 15:00 | KVV Coxyde - KSV Temse | - | |
| 10 | 17/10/2010 15:00 | KSV Temse - KSV Oudenaarde | - | |
| 11 | 24/10/2010 15:00 | KRC Waregem - KSV Temse | - | |
| 12 | 30/10/2010 20:00 | KSV Temse - KFC Dessel Sport | - | |
| 13 | 06/11/2010 20:00 | Hoogstraten VV - KSV Temse | - | |
| 14 | 13/11/2010 20:00 | KSV Temse - KM Torhout 92 | - | |
| 15 | 20/11/2010 19:30 | KSV Temse - KRC Waregem | - | |
| 16 | 21/11/2010 15:00 | KSV Temse - VW Hamme | - | |
| 17 | 27/11/2010 20:00 | KMSK Deinze - KSV Temse | - | |
| 18 | 05/12/2010 14:30 | KSV Bornem - KSV Temse | - | |
| 19 | 12/12/2010 15:00 | KSK Ronse - KSV Temse | - | |
| 20 | 18/12/2010 20:00 | KSV Temse - KFC Izegem | - | |
| 21 | 09/01/2011 14:30 | SK Sint-Niklaas - KSV Temse | - | |
| 22 | 15/01/2011 20:00 | KSV Temse - Verbr. Geel-Meerhout | - | |
| 23 | 23/01/2011 14:30 | SC Wielsbeke - KSV Temse | - | |
| 24 | 29/01/2011 20:00 | KSV Temse - OLSA Brakel | - | |
| 25 | 05/02/2011 20:00 | KSV Temse - R. Cappellen FC | - | |
| 26 | 20/02/2011 15:00 | VC Eendracht Aalst 2002 - KSV Temse | - | |
| 27 | 26/02/2011 20:00 | KSV Temse - KVV Coxyde | - | |
| 28 | 05/03/2011 19:30 | KSV Oudenaarde - KSV Temse | - | |
| 29 | 19/03/2011 20:00 | KSV Temse - KRC Waregem | - | |
| 30 | 26/03/2011 19:30 | KFC Dessel Sport - KSV Temse | - | |
| 31 | 02/04/2011 20:00 | KSV Temse - Hoogstraten VV | - | |
| 32 | 09/04/2011 19:30 | KM Torhout 92 - KSV Temse | - | |
| 33 | 16/04/2011 20:00 | KSV Temse - KMSK Deinze | - | |
| 34 | 01/05/2011 15:00 | KSV Temse - KSV Bornem | - | |
| 35 | 08/05/2011 15:00 | VW Hamme - KSV Temse | - | |
